Swine flu (swine influenza) is a respiratory disease caused by viruses (influenza viruses). Neuraminidase inhibitors class of antiviral drug used for treating and preventing flu. Mainly oseltamivir (Tamiflu) and zanamivir (Relenza), Laninamivir (Inavir), and Peramivir belong to neuraminidase inhibitors act against both influenza A and influenza B. Swine flu is resistant to M2 ion channel protein ligand drugs amantadine (Symmetrel) and rimantadine (Flumadine). The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control and pharmacodynamics and pharmacokinetic studies. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of swine flu drugs in bulk drugs, formulations and biological samples have been reviewed. This review covers the time period till 2012 during which many methods including spectroscopic, chromatographic titrimetric methods were reported. The application of these methods for the determination of swine flu drugs in pharmaceutical formulations has also been discussed.
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